Synthesis and Transformation of Mono - and Dicarboxylic Acids with Its Complimentory Anilides | Original Article

ABSTRACT:

The fascination of is thiocyanates as synthons and as cyclizing operators proceeds because of their diverse responses and because of their simple accessibility. It would not be strange to refer to that, in comparison to isocyanates (- N=C=O), their Sulfur analogs, is thiocyanates (- N=C=S), are less terrible and somewhat less hazardous. The utilization of isocyanates is radically restricted by the analysts [6] after December 3, 1984 which is the date of Bhopal Disaster held in Union carbide factory, Bhopal, Madhya Pradesh (India) because of the spillage of Methyl isocyanate (MIC) where a huge number of individuals were died because of the toxic impact of MIC (Me-N=C=O). In the present study, a blend of Phenyl is thiocyanate (2) and monocarboxylic acid (1), in the proportion of 11 and Phenyl is thiocyanate (2) and dicarboxylic acid (4) in the proportion of 21are taken for buildup response by warming at 160°-170°C for 15 minutes under solvent free condition. Pyridine was utilized as an impetusbase in both the cases. The items acquired were monoanilides (3) and dianilides (5) of mono-and dicarboxylic acids individually, which were recrystallized from aqueous ethanol. Dicarboxylic acids gave startling outcomes in a portion of the cases. The response of a chloroformate or di-tert-butyl dicarbonate and sodium azide with an aromatic carboxylic acid delivers the corresponding acyl azide, apparently through the arrangement of an azidoformate. The acyl azide experiences a Curtius revision to shape an isocyanate derivative, which is caught either by an alkoxide or by an amine to frame the aromatic carbamate or urea. For instance, phthalic acid produces N-phenylphthalimide independent of the molar proportion of the acid and Phenyl is thiocyanate though maleic acid produces neither mono-nor dianilifisdes with Phenyl are thiocyanate under the current condition. An appropriate deliberate investigation was done towards the buildup of Phenyl is thiocyanate with mono-and dicarboxylic acids.