The Role of Sambucus nigra Extracts in Animal Models of High Blood Pressure | Original Article

ABSTRACT:

Natural polyphenols are well-known to have the chemical and physical qualities that help protect vital biomolecules including lipids, proteins, and nucleic acids against oxidation. Specific enzymatic measurements and non-specific indicators were used to assess the level of oxidative stress in experimentally produced arterial hypertension by the administration of L-NAME. Results demonstrated the antioxidant and protective effect of Sambucus nigra extract on biochemical markers and histological changes in experimental arterial hypertension. Glutathione-peroxidase and superoxide-dismutase activities are markedly reduced in the hypertension group compared to the polyphenol-protected group. The polyphenolic extract of Sambucus nigra may be useful as a nutritional supplement in chronic cardiovascular and metabolic illnesses if its effects on the functionality of endothelial cells, such as membrane sensitivity and intracellular signalling, are understood.