Development of mouth dissolves tablets of Cinnarizine by Effervescent, Superdisintegrant addition and Sublimation Methods | Original Article

ABSTRACT:

As a result of challenges associated with swallowing, there has been a recent uptick in the demand for tablets that may be dissolved in the mouth. This trend has been observed particularly among elderly and juvenile patients. Cinnarizine, an H1-receptor antagonist, is a common medication for treating motion sickness, vomiting, and vertigo. Cinnarizine tablets that dissolve in the mouth were made using effervescent, superdisintegrant addition, and sublimation processes respectively. Since the Superdisintegrant addition method resulted in the quickest disintegration time, it was selected for further study. For the next nine batches, we diluted model drug, carboxymethylcellulose salt, and L-HPC to various concentrations (B1-B9) The range of strengths covered was from 5 to 10.It was determined how much each formulation varied in weight, how hard it was, how friable it was, how much active ingredient it contained, how long it took to disintegrate in vitro, how long it took to wet in vitro, and how well it dissolved in vitro. The formulation that contained 10 L-HPC exhibited a shorter disintegration time of 25.3 seconds and a shorter wetting time (29.1 seconds). In-vitro dissolving tests demonstrated that the whole dose of medication was released within just six minutes.