Behavior of Adrenal Ectomized Rats In Chloro-Hydroxy Derivatives of Phenothiazine

Published in Journal

Journal of Advances and Scholarly Researches in Allied Education [JASRAE] (Vol:16/ Issue: 9) DOI: 10.29070/JASRAE
Authors: Mamta Patidar, Vikrant Jain*,
Subjects: Multidisciplinary Academic Research

Year: Jun, 2019
Volume: 16 / Issue: 9
Pages: 1778 - 1780 (3)
Publisher: Ignited Minds Journals
Source:
E-ISSN: 2230-7540
DOI:
Published URL: http://ipublisher.in/p/305231
Published On: Jun, 2019

Article Details

Behavior of Adrenal Ectomized Rats in Chloro-Hydroxy Derivatives of Phenothiazine | Original Article

Mamta Patidar, Vikrant Jain*, in Journal of Advances and Scholarly Researches in Allied Education | Multidisciplinary Academic Research

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ABSTRACT:

Several new Chloro-hydroxy derivatives of phenothiazine such as N10 -[ɐ - (Benzlidene hydrazino)acetyl] 8-chloro 3-hydroxy phenothiazine 2-carboxyalic acid and 2-Substituted aryl, 3- N10 [(acetyl amino)1,3-thiazolidin 4-ones] 8-chloro 3-hydroxy phenothiazine 2-carboxyalic acid have been synthesized and tested for their antimicrobial and anti-inflammatory activities. Structure of the synthesized compounds have been elucidated on the basis of their elemental analysis and spectral data. 8-chloro 3-hydroxy phenothiazine 2-carboxyalic acid produced a significant inhibition of granuloma growth in Carrageenan filter paper granuloma assay in adrenal ectomized rats.