Synthesis of Benzofuran and Schiff’s Base Derivatives and Its Biological Study | Original Article

ABSTRACT:

Schiff bases are very important class of ligands which can bind to the metal via azomethine nitrogen and have been extensively studied in the recent years. Benzofuranle Schiff base ligands acts as a scaffold for the synthesis of metal complexes, to fight against infectious diseases. the synthesis of 2-(1methyl-1-H-Benzofuranl-2-yl)phenyl)imino)methyl)phenol ligand and used it for the preparation of dicopper metal complexes. Both ligand and its complexes are characterized by various spectroscopic techniques including IR, NMR, ESI-MS and single crystal X-ray crystallography. As per the biological activity is concerned, binding study with DNA and BSA have been carried out, results are suggested that the metal complex bind in a partial intercalativeelectrostatic interactions and was shown to have better binding affinity than ligand. Also, cytotoxic effects were studied on human breast cancer cells (MCF-7), IC50 values reveals that metal complex was found to be better cytotoxic activity than ligand. Besides the biological activity, the fluorescent property of Benzofuran [1,2-c] quinazoline have led researchers to explore the property for the welfare of mankind. One such advantage is the use of luminescent organic compound in the optoelectronic devices like solar cells and organic light emitting diodes (OLEDs). Synthesized monomeric and dimeric Benzofuran quinazoline derivatives and characterized by elemental analysis, IR, NMR, ESI-MS and single crystal X-ray crystallographic techniques. Photophysical properties were studied by UV-vis and fluorescence spectroscopic analysis. The compounds were doped with 1,3-bis(9-carbazolyl)benzene at different concentrations, which were made into thin films and then emission spectra were recorded. The results reveal that long range emission spectrum in the visible region and thermal stability of the synthesized compounds may act as promising molecules for OLED application.