Studies of Some Coordination Compounds with Schiff-Base Ligand Drived From Carbonyl and Amino “Hydroxamic” Acid | Original Article

ABSTRACT:

Schiff bases are versatile organic compounds typically used and synthesized by the condensation process of various aldehyde or ketone amino compounds such as imine. As they are easily synthesized by condensation, Schiff base ligands are classified as privileged ligands. They demonstrate a wide variety of uses and are often used as an O2 detector in medication, pharmacy, teamwork chemistry, biological processes, industries, product packets, dyes, and polymers. Semi carbazone is a derivative of imine derived from semi carbazide condensation and ideal for aldehyde and ketone. Excellent precursors for the production of metal or metal chalcogenide nanoparticles have been shown by imine ligands comprising transition metal complexes such as copper , zinc, and cadmium. In recent years , due to various pharmacological uses such as antiviral , antifungal, antimicrobial, antimalarial, antituberculosis, anticancer, anti-HIV, catalytic use in organic compound oxidation, and nanotechnology, researchers have drawn tremendous attention to Schiff bases, semi carbazones, thiosemicarbazones, and their metal complexes. The synthesis, structural, biochemical, and catalytic application of Schiff bases as well as their metal complexes are summarized in this study. Due to the capacity to chelate biologically essential metal ions to modulate different enzymes such as HDACs, urease, metallopeptidase, and carbonic anhydrase, substituted hydroxamic acid is one of the most widely researched pharmacophores. Syntheses and biological studies of various groups of hydroxamic acid derivatives have been published in multiple research articles in recent years, but this is the first study paper dedicated to their synthetic methods and their application for the synthesis of these specific molecules.