Synthesis of Diorganosilicon (Iv) Complexes of 3-Hydroxy-2-Pyridine Carboxylic Acid and 2-Pyridine Carboxylic Acid |

ABSTRACT:

Pyridinecarboxylic acids and their derivatives belong to the category of legendspresent in natural products as well as in biological systems. They are ofspecial interest to medicinal chemists, because of the wide variety ofphysiological properties displayed by the natural and many syntheticderivatives. Nicotinic acid and nicotinamide present in cells as the pyridinenucleotides, belong to coenzymes and vitamins and are necessary for theirmetabolism. They are also important from the industrial point of view; forexample, vanadium 2-pyridine carboxylic acid complexes are used in the nuclearreactor decontamination process. 2-Pyridine carboxylic acid is formed in thebody as an intermediate in the triptophan degradation pathway and it is also anapproved food supplement. In addition, Chromax, is the trade mark name of thechromium 2-pyridine carboxylic acid complex, which is currently being used as afood additive and has been shown to assist diabetic patients in maintainingglycemic control.