Article Details

A Research on Synthesis of Ligands and Metal Complex: Antimicrobial, Antibacterial and Antifungal Screening | Original Article

Priyanka .*, Praveen Kumar, in Journal of Advances and Scholarly Researches in Allied Education | Multidisciplinary Academic Research

ABSTRACT:

The synthesis, characterisation and antimicrobial study of Ni(II) complexes from Schiff base ligands L1 and L2 are recorded in this study. The ligand L1, 2-((2-hydroxy-3-methoxybenzylidene)amino) benzoic acid obtained by the condensation of o-vanillin and 2-aminobenzoic acid and the ligand L2, 2-((2-hydroxybenzylidene) amino)benzoic acid is obtained by the condensation of salicylaldehyde and 2-aminobenzoic acid. The ligands and the complexes were characterised by molar conductance, vibrational, electronic, 1H-NMR spectrum and redox sudies. The molar conductance of these complexes convey the non-ionic character of the complexes. Novel binuclear metal complexes of general formula [M2(PymL)X3] (where M = Cu(II), Ni(II), Co(II) or Zn(II) X = Cl− or CH3CO2− and PymL = C13H17N4O6) were synthesized by template condensation of Schiff base (L) derived from glycine using 2,3-butanedione, 5-methyl-2,6-pyrimidine-dione and metal chlorideacetate salt in 112 stoichiometric ratio. Synthesized compounds were characterized by elemental analysis, conductance measurement, magnetic measurement, IR, UV–visible, 1H NMR, 13C NMR, EPR and ESI-MS spectral studies. IR spectral data suggest that Schiff base (L) behaves as tetradentate ligand with two nitrogen and two oxygen donor sites of the azomethine group and carboxylic group, respectively and 5-methyl-2,6-pyrimidine-dione behaves as tridentate ligand with two oxygen atoms of the carbonyl group and one nitrogen atom of pyrimidine ring as binding sites. Physico-chemical data suggest octahedral geometry and non-electrolytic nature of metal complexes.