Dietary Supplementation With Beetroot Juice (Br) Containing ~5-8 Mmol of Inorganic Nitrate (No3-) Increases Plasma Nitrite Concentration ([No2-]), Reduces Blood Pressure, and May Positively Influence the Physiological Responses to Exercise. However, the Dose-Response Relationship Between the Volume of Br Ingested and the Physiological Effects Invoked Has Not Been Investigated. In a Balanced Crossover Design, 10 Healthy Males Ingested 70, 140 or 280 Ml of Concentrated Br (Containing 4.2, 8.4 and 16.8 Mmol No3-, Respectively) or No Supplement to Establish the Effects of Br on Resting Plasma [No3-] and [No2-] Over 24 H. Subsequently, on Six Separate Occasions, 10 Subjects Completed Moderate-Intensity and Severe-Intensity Cycle Exercise Tests 2.5 H Post-Ingestion of 70, 140 and 280 Ml Br, or No3- -Depleted Br As Placebo (Pl). In a Randomized Open Design, 100 Male Healthy Volunteers Aged Between 12-30 Years Are Assigned to Consume the 250 Ml of Beetroot Juice For Three Consecutive Days Up to 9 Weeks Period. Present Study Demonstrate That Dietary No3-, Administered In the Form of Beetroot Juice (250 Mlday For 9 Weeks), Decreases Systolic Blood Pressure (Sbp). These Results May Provide a Mechanism By Which Nitrate Exerts Beneficial Effects on Muscle Function With Applications to Sports Performance and a Potential Therapeutic Role In Conditions With Muscle Weakness.