Present Study Manages an Appraisal of some Physicochemical Parameters of the Yamuna River at Mathura. the Study Territoryencounters a Regular Atmosphere and Comprehensively Partitioned into Threeseasons As Winter (November to February), Summer (March to June) and Blustery(July to October). the Examples Were Gathered and Investigated For Two Sequentialyears 2011 and 2012. Examination of some Physico-Chemical Aspects Like, Watertemperature, Ph, D.O. (Mg/L), Bod (Mg/L), C.O.D. (Mg/L), and T.D.S. (Mg/L) Hasbeen Carried Out Amid the Examination Period. the Water Ph of River Ran from Abase 7.2 and 8.3 In Summer D.O 3.0 to 10.4 In Winters B.O.D. 14.0 to 52.7 Insummers and C.O.D. 11.4 to 35.2 In Winters While As T.D.S. 460 to 553Indownpours. Customarily, the River Pollution Has Been Broadlycontemplated As to Physical and Chemical Attributes. Then Again, Recentlymicrobiological Nature of the River Has Gone Under More Prominent Center Owingto Injurious Impacts of Pollution on Human Health, Particularly In Theconnection of Designated Best Use (Dbu) of the River Waters. With This Purpose,The Paper Presents Pollutional Parts of River Yamuna at Delhi, the Capital Ofindia, Amid Lean the Period. Out of Huge Number of Microbial Parametersconnected With Human Health, some Noteworthy Sullying Pointers, Specifically,Heterotrophic Plate Check (Absolute Plate Number, Cfu/Ml), Downright Coliform(Mpn/100 Ml), Fecal Coliform (Mpn/100 Ml), Pathogenic Parasites, In Particular,Helminths (Eggs/L), Coliph ...