An Evolutionary Conserved Mechanism That Detects and Fights Off Illness and Discomfort Is The
Innate Immune System. Through a Variety of Germline-Encoded Cell Surface or Cytoplasmic Receptors,
Innate Immune Signalling Rapidly Detects Infectious Threats and Delivers Signals For the Application Of
Appropriate Defences Through Adaptors, Kinases, and Transcription Factors, Leading to the Generation Of
Cytokines. Inflammatory Reactions, Which Are the Innate Immune System's Initial Response to Pathogenic
Signals, Must Be Quick and Focused In Order to Create a Physical Barrier Against the Spread of Infection
And Must Then Be Stopped Once the Pathogens Have Been Eradicated.
The Human Pathogen Mycobacterium Tuberculosis, Which Largely Attacks Innate Immune Cells Patrolling
The Lung, Is What Causes Tuberculosis (Tb). By Identifying the Inflammatory Environment In the Lungs And
Encouraging the Development of Adaptive Immune Responses, Innate Immune Cells Act As Barometers Of
The Immune Response Against Mycobacterium Tuberculosisinfection. However, M. Tb Can Easily Control
Innate Immune Cells, Which Are Also Potential Habitats For Bacterial Proliferation. Particularly In The
Context of Human Infection, Our Knowledge of the Early Interactions Between M. Tb and Innate Immune
Cells Is Restricted. This Review Will Concentrate on Innate Immune Pathways Discovered Through Human
Immunogenic Research.