Mycobacterium Tuberculosis (M. Tb) Causes Tb and Kills Millions Worldwide. Immune-Dependent
Tissue-Damaging Inflammation Promotes Aerosol Transmission, Making This Disease Ubiquitous. Since
Type I Ifns Play a Debatable Role In Tb and Their Induction Precedes Clinical Tuberculosis In Patients, This
Study Sought to Identify a Pattern (Absolute Levels and Relative Ratios) In Interferon and Regulatory Molecule
Expression Levels That Correspond With Tb Patients and Pulmonary Versus Extra Pulmonary Tb. Using an In
Vitro M. Tb Thp-1 Infection Model and Antibody-Based Neutralization of Specific Interferons, We Found That
Modulating Interferon Production Promotes Intracellular Bacterial Burden or Clearance.
Real-Time Pcr Was Performed to Compare Ifn Alpha, Beta, and Gamma Fold Mrna Expression In 123
Untreated Tb Patients (Ptb - 56 Eptb - 67) and 86 Healthy Family Contacts Clinically Clear of Tb. Eptb
And Ptb Patients' Three Ifn Expression Levels Were Compared. Elisa For Interleukin-1Β, -1Α, And
Prostaglandin E2 Was Done on Sera from 62 Tb Patients and 18 Healthy Contacts from the Same
Residence.
Tb Patients Expressed More Ifn-Α Than Counterparts. Ifn-Α Had the Highest Median Fold Mrna
Expression (0.80) In Untreated Tb Patients. Ptb Patients Had a Median Fold Mrna Expression Level Of
Ifn- (0.87) That Was Higher Than Eptb Patients'. Eptb Patients Expressed 0.81 Times More Ifn-Α Than
Ptb Patients. the Three Ifns Were Measured In Matched Samples from Each Patient at Enrolment And
After Tr ...