The Clinical Use of Blood Is One of a Number of Learning Resources Produced By Whobts to Support the Organization's Worldwide Blood Safety Policy. It Focuses on the Clinical Aspects of Blood Transfusions and Seeks to Demonstrate How Needless Transfusions May Be Eliminated at All Levels of the Health-Care System In any Nation Without Jeopardizing Quality and Safety Requirements. the Purpose of This Research Was to Determine the Frequency, Origin, and Type of Unexpected Red Cell Antibodies In a Large Group of Whole Blood Donors In North India. from January Through December, Blood Donor Samples Were Tested For Antibodies In This Three-Year Prospective Observational Research. In Our Donor Group, Red Cell Antibodies Were Found In 0.17 of the Time. 86.7 Donors With Red Cell Antibodies Had Alloantibodies, 10.5 Had Autoantibodies, and Eight Donors 2.8 Had Positive Antibody Screening With Ambiguous Findings. Current Transfusion Procedures Make All Immunization to Red Cell Antigens a Difficult Job. Antibody Testing In Blood Donors Has the Potential to Enhance the Quality and Safety of Blood Transfusions For Recipients. It Also Lowers the Chance of Problems from Blood Transfusions That Aren't Compatible.