More Than 30Years After the First Report of Successfulvaccination Against Malaria Using Radiation-Attenuated Sporozoites, Aneffective Malaria Vaccine Is Not Yet Available. However, Field and Experimentaldata Indicate That It Can Be Developed. an Astonishing Amount of Data Hasaccumulated Concerning Parasite Biology, Host-Parasite Interactions, Immunityand Escape Mechanisms, Targets and Modulators of Immune Responses.Nevertheless, So Far This Knowledge Has Not Been Enough to Make Us Understandhow to Properly Manipulate the Whole System to Build an Effective Vaccine. Inthis Article, We Describe Candidate Antigens, Mechanisms, Targets and Trialsperformed With Potential Malaria Vaccines and Discuss the Approaches, In Vivoand In Vitro Models, Constraints and How Technologies Such As Dna Vaccination, Genomics/Proteomics and Reverse Immunogeneticsare Providing Exciting Results and Opening New Doors to Make Malaria Vaccine Areality. Malaria Remains One of the Most Prevalent Parasitizesworldwide. About 350 to 500 Million Febrile Episodes Are Observed Yearly Inafrican Children Alone and More Than 1 Million People Die Because of Malariaeach Year. Multiple Factors Have Hampered the Effective Control of Thisdisease, some of Which Include the Complex Biology of the Plasmodium Parasites,Their High Polymorphism and Their Increasingly High Resistance to Antimalarialdrugs, Mainly In Endemic Regions. the Ancient Interaction Between Malarialparasites and Humans Has Led to the Fixation In the Popu ...