One of the Most Popular Administration Routes from Complications Moderate to Severe Is the Parenteral Route and the Complaince to Patients Is Significantly Lower For Such Delivery Mode Since It's Is a Technique Too Invasive and Need Needle Pricking. Further This Becomes Evident That Absorption Rate Quality and the Metabolic Elimination Rate Leads to the Distribution of Equilibrium of Tissues of Drug and of Blood However, It Is Not Present In the Drug Dosage Form. the System of Drug Delivery Would Be In the Form of Controlled System of Drug Delivery and Also There Is a System Predictive Control Across the Release Pattern Along With Blood Vessels and the Subsequent Tissues That Are Achievable the Absorption and the Metabolism Rate Can Be Seen In Delivery System of Rectal Drug.