Black Nightshade or the Technical Term- Solanum Nigrum (Sn), Aka Makoi Has a Range of Ayurvedic Properties and Known Widely For the Medicinal Benefits. But, This Does Not Affirm That It Would Garner Attention of the Therapeutic Users. Given In the Study, Researchers Perform Characterization, Synthesis, and the Cream's Antibacterial Evaluation from Solanum Nigrum Extract. As Seen In India, Solanum Nigrum Has Been Combined With Different Medicinal Plants and Seen to Have a Protective Hepatic Impact on the Patients Suffering from Liver Cirrhosis. the Impact Can Be Attributed to the Action Antioxidant, Diuretic, Immuno Modulating and the Anti-Inflammatory Drug.